Major drama following the penultimate round of the regular season, with South Sydney superstar Latrell Mitchell suspended for six weeks for a high shot on Joseph Manu.
The fullback will miss the entire finals series, while Manu won't be back in 2021 after undergoing facial reconstruction surgery.
Elsewhere, the likes of Melbourne, Penrith and Parramatta are expected to rest some of their big guns as the finals series nears.
Here's how every side is likely to line up in round 25.
To see how your side lined up in round 24, click here.
CANBERRA RAIDERS VS SYDNEY ROOSTERS
Thursday 2nd September, BB Print Stadium (7.50pm)
Raiders predicted team:
1. Jordan Rapana
2. Bailey Simonsson
3. Seb Kris
4. Matt Timoko
5. Harley Smith-Shields
6. Jack Wighton
7. Matt Frawley
8. Josh Papalii
9. Josh Hodgson
10. Joseph Tapine
11. Hudson Young
12. Elliott Whitehead
13. Ryan Sutton
14. Charnze Nicoll-Klokstad
15. Emre Guler
16. Corey Horsburgh
17. Siliva Havili
Raiders team news:
No changes expected at this stage following the win over the Warriors.
Joseph Tapine (knee) and Bailey Simonsson (groin) are in some doubt but are expected to be named at this stage.
Roosters predicted team:
1. James Tedesco
2. Daniel Tupou
3. Lachlan Lam
4. Adam Keighran
5. Brad Abbey
6. Drew Hutchison
7. Sam Walker
8. Jared Waerea-Hargreaves
9. Sam Verrills
10. Sio Siua Taukeiaho
11. Angus Crichton
12. Sitili Tupouniua
13. Isaac Liu
14. Ben Marschke
15. Egan Butcher
16. Ben Thomas
17. Naufahu Whyte
Roosters team news:
Huge blow for the Roosters, with superstar centre Joseph Manu (facial fracture) set to miss the remainder of the season.
Adam Keighran (HIA) will likely return and take his place at centre, while Jared Waerea-Hargreaves (knee) and Angus Crichton (suspension) are both expected to return.
Fletcher Baker is facing suspension for a crusher tackle.
CRONULLA SHARKS VS MELBOURNE STORM
Friday 3rd September, Cbus Super Stadium (6pm)
Sharks predicted team:
1. Will Kennedy
2. Sione Katoa
3. Connor Tracey
4. Jesse Ramien
5. Mawene Hiroti
6. Luke Metcalf
7. Braydon Trindall
8. Toby Rudolf
9. Blayke Brailey
10. Aaron Woods
11. Briton Nikora
12. Siosifa Talakai
13. Jack Williams
14. Matt Moylan
15. Braden Hamlin-Uele
16. Aiden Tolman
17. Teig Wilton
Sharks team news:
No changes expected to the side that defeated Brisbane in round 24.
Storm predicted team:
1. Ryan Papenhuyzen
2. Dean Ieremia
3. Reimis Smith
4. Justin Olam
5. Isaac Lumelume
6. Cameron Munster
7. Jahrome Hughes
8. Tui Kamikamica
9. Harry Grant
10. Christian Welch
11. Felise Kaufusi
12. Kenny Bromwich
13. Brandon Smith
14. Nicho Hynes
15. Tom Eisenhuth
16. Nelson Asofa-Solomona
17. Tepai Moeroa
Storm team news:
Jesse Bromwich is facing a one-game ban for a crusher tackle, with Tui Kamikamica likely coming into the starting side.
Josh Addo-Carr (hamstring) will also be sidelined for at least a week after picking up an injury against Parramatta.
Expect to see Craig Bellamy rest a bunch of players for this game.
PARRAMATTA EELS VS PENRITH PANTHERS
Friday 3rd September, Cbus Super Stadium (8.05pm)
Eels predicted team:
1. Will Smith
2. Haze Dunster
3. Will Penisini
4. Waqa Blake
5. Blake Ferguson
6. Dylan Brown
7. Mitchell Moses
8. Isaiah Papali'i
9. Joey Lussick
10. Makahesi Makatoa
11. Bryce Cartwright
12. Marata Niukore
13. Nathan Brown
14. Ray Stone
15. Keegan Hipgrave
16. Wiremu Greig
17. Oregon Kaufusi
Eels team news:
Clint Gutherson (knee) picked up a minor injury against Melbourne, with coach Brad Arthur confirming he would not play in round 25.
Junior Paulo is facing suspension for a shoulder charge, with Makahesi Makatoa likely to come into the starting side and Wiremu Greig (ankle) join the bench.
Shaun Lane (HIA) and Marata Niukora (HIA) both suffered head knocks in the same game.
Panthers predicted team:
1. Dylan Edwards
2. Stephen Crichton
3. Paul Momirovski
4. Matt Burton
5. Brian To'o
6. Jarome Luai
7. Nathan Cleary
8. Moses Leota
9. Api Koroisau
10. James Fisher-Harris
11. Viliame Kikau
12. Kurt Capewell
13. Isaah Yeo
14. Mitch Kenny
15. Scott Sorensen
16. Tevita Pangai Junior
17. Liam Martin
Panthers team news:
Ivan Cleary opted for Tyrone May in the utility spot over Mitch Kenny on the weekend, so it will be interesting to see which way he goes moving into the finals.
Penrith may opt to rest some players in the final round of the regular season.
BRISBANE BRONCOS VS NEWCASTLE KNIGHTS
Saturday 4th September, Suncorp Stadium (3pm)
Broncos predicted team:
1. Tesi Niu
2. Corey Oates
3. Selwyn Cobbo
4. Herbie Farnworth
5. Xavier Coates
6. Anthony Milford
7. Albert Kelly
8. Rhys Kennedy
9. Jake Turpin
10. Payne Haas
11. Alex Glenn
12. Jordan Riki
13. Kobe Hethrington
14. Danny Levi
15. Ethan Bullemor
16. TC Robati
17. Lucky Taavale
Broncos team news:
Two more blows in the forwards, with Brendan Piakura and Tom Flegler both facing suspensions following the loss to Cronulla.
Jordan Riki (ankle) will likely return in the second-row and push TC Robati to the bench.
Knights predicted team:
1. Kalyn Ponga
2. Enari Tuala
3. Kurt Mann
4. Bradman Best
5. Hymel Hunt
6. Jake Clifford
7. Mitchell Pearce
8. David Klemmer
9. Jayden Brailey
10. Jacob Saifiti
11. Tyson Frizell
12. Mitchell Barnett
13. Connor Watson
14. Brodie Jones
15. Chris Randall
16. Josh King
17. Sauaso Sue
Knights team news:
David Klemmer (suspension) will return in the front-row, pushing Sauaso Sue to the bench.
No other changes expected after the win over the Titans, with rep forward Daniel Saifiti (knee) still another week away.
NORTH QUEENSLAND COWBOYS VS MANLY SEA EAGLES
Saturday 4th September, Queensland Country Bank Stadium (5.30pm)
Cowboys predicted team:
1. Hamiso Tabuai-Fidow
2. Kyle Feldt
3. Valentine Holmes
4. Ben Hampton
5. Murray Taulagi
6. Scott Drinkwater
7. Tom Dearden
8. Jason Taumalolo
9. Reece Robson
10. Jordan McLean
11. Ben Condon
12. Jeremiah Nanai
13. Reuben Cotter
14. Jake Granville
15. Heilum Luki
16. Mitchell Dunn
17. Griffin Neame
Sea Eagles predicted team:
1. Tom Trbojevic
2. Jason Saab
3. Brad Parker
4. Morgan Harper
5. Reuben Garrick
6. Kieran Foran
7. Daly Cherry-Evans
8. Josh Aloiai
9. Lachlan Croker
10. Martin Taupau
11. Haumole Olakau'atu
12. Josh Schuster
13. Jake Trbojevic
14. Dylan Walker
15. Karl Lawton
16. Curtis Sironen
17. Toafofoa Sipley
Sea Eagles team news:
No changes expected to the Manly outfit, with Des Hasler unlikely to rest players as they battle for a top four spot.
SOUTH SYDNEY RABBITOHS VS ST GEORGE ILLAWARRA DRAGONS
Saturday 4th September, Sunshine Coast Stadium (7.35pm)
Rabbitohs predicted team:
1. Blake Taaffe
2. Alex Johnston
3. Dane Gagai
4. Campbell Graham
5. Jaxson Paulo
6. Cody Walker
7. Benji Marshall
8. Mark Nicholls
9. Peter Mamouzelos
10. Tom Burgess
11. Jaydn Su'A
12. Jai Arrow
13. Cameron Murray
14. Jacob Host
15. Tevita Tatola
16. Hame Sele
17. Patrick Mago
Rabbitohs team news:
Latrell Mitchell (suspension) won't play again this year, after he was banned for six weeks for a high shot on Joseph Manu. Expect to see rookie Blake Taaffe slot in at fullback for the rest of the year.
Adam Reynolds (knee) and Damien Cook (leg) will likely both be rested for the final round, with Benji Marshall and Peter Mamouzelos coming into the starting side.
Wayne Bennett may be tempted to rest some of his other big guns for the final game of the regular season.
Dragons predicted team:
1. Tyrell Sloan
2. Mat Feagai
3. Jack Bird
4. Zac Lomax
5. Mikaele Ravalawa
6. Junior Amone
7. Corey Norman
8. Blake Lawrie
9. Jayden Sullivan
10. Josh McGuire
11. Billy Burns
12. Tariq Sims
13. Jack de Belin
14. Freddy Lussick
15. Tyrell Fuimaono
16. Daniel Alvaro
17. Jackson Ford
Dragons team news:
No changes flagged at this stage despite the loss to the Cowboys.
Ben Hunt (arm) could be back from injury, but with finals now out of the equation, there may not be any point in risking him for one game.
GOLD COAST TITANS VS NEW ZEALAND WARRIORS
Sunday 5th September, Cbus Super Stadium (2pm)
Titans predicted team:
1. Jayden Campbell
2. Phillip Sami
3. Brian Kelly
4. Patrick Herbert
5. Corey Thompson
6. Tyrone Peachey
7. Jamal Fogarty
8. Jarrod Wallace
9. Mitch Rein
10. Tino Fa'asuamaleaui
11. Kevin Proctor
12. Beau Fermor
13. Sam McIntyre
14. Erin Clark
15. David Fifita
16. Moeaki Fotuaika
17. Jaimin Jolliffe
Titans team news:
No changes flagged at this stage despite the loss to Newcastle.
Warriors predicted team:
1. Reece Walsh
2. Dallin Watene-Zelezniak
3. Peta Hiku
4. Rocco Berry
5. Marcelo Montoya
6. Sean O'Sullivan
7. Chanel Harris-Tavita
8. Addin Fonua-Blake
9. Wayde Egan
10. Bunty Afoa
11. Josh Curran
12. Euan Aitken
13. Bayley Sironen
14. Kodi Nikorima
15. Eliesa Katoa
16. Kane Evans
17. Jazz Tevaga
Warriors team news:
Matt Lodge is facing suspension, ending his season in the process. Bunty Afoa will start at prop and Jazz Tevaga will come onto the bench.
Chanel Harris-Tavita (foot) will likely come back into the side after missing round 24.
WESTS TIGERS VS CANTERBURY BULLDOGS
Sunday 5th September, Moreton Daily Stadium (4.05pm)
Tigers predicted team:
1. Moses Mbye
2. David Nofoaluma
3. Tommy Talau
4. Michael Chee Kam
5. Ken Maumalo
6. Jock Madden
7. Luke Brooks
8. Thomas Mikaele
9. Jacob Liddle
10. James Tamou
11. Shawn Blore
12. Luciano Leilua
13. Alex Twal
14. Joe Ofahengaue
15. Jake Simpkin
16. Tom Amone
17. Tuki Simpkins
Tigers team news:
Alex Seyfarth (knee) suffered an MCL injury against Penrith and will be unavailable. Tuki Simpkins will likely take his place on the bench.
James Tamou (foot) is expected back this week.
Bulldogs predicted team:
1. Nick Meaney
2. Corey Allan
3. Will Hopoate
4. Aaron Schoupp
5. Jayden Okunbor
6. Brandon Wakeham
7. Kyle Flanagan
8. Ava Seumanufagai
9. Sione Katoa
10. Jack Hetherington
11. Matt Doorey
12. Joe Stimson
13. Josh Jackson
14. Bailey Biondi-Odo
15. Ofahiki Ogden
16. Chris Patolo
17. Jackson Topine
Bulldogs team news:
No changes expected to the side following a solid performance against Manly.
Dylan Napa (suspension) will be available but is no guarantee of earning a spot in the side.